Motif ID: MEF2{A,B,C,D}.p2

Z-value: 2.839


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MEF2Cchr5_-_882356240.775.0e-04Click!
LOC729991-MEF2Bchr19_-_19164222-0.533.4e-02Click!
MEF2Achr15_+_979907050.448.9e-02Click!
MEF2Dchr1_-_1547371300.312.5e-01Click!
MEF2Bchr19_-_19142090-0.194.9e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_111119846 8.437 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr12_+_79625538 7.589 NM_002469
MYF6
myogenic factor 6 (herculin)
chr10_+_69539255 7.498 NM_032578
MYPN
myopalladin
chr4_+_169654742 6.542 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr5_+_155686333 6.418 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr10_-_75085754 6.003 NM_001114133
SYNPO2L
synaptopodin 2-like
chrX_-_21686079 5.810 NM_014332
SMPX
small muscle protein, X-linked
chr2_+_88148413 5.539 NM_198274
SMYD1
SET and MYND domain containing 1
chr10_-_75080784 4.893 NM_024875
SYNPO2L
synaptopodin 2-like
chr2_+_170074457 4.863 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr8_+_67201684 4.834 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr7_-_41709191 4.650 NM_002192
INHBA
inhibin, beta A
chr15_-_68781662 4.616 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr10_+_50177192 4.276 NM_001135196
NM_199459
C10orf71

chromosome 10 open reading frame 71

chr2_-_190635566 4.233 NM_005259
MSTN
myostatin
chr5_+_53787187 4.219 NM_006308
HSPB3
heat shock 27kDa protein 3
chr16_+_31132842 4.187 NM_001008274
TRIM72
tripartite motif containing 72
chr7_+_93862137 3.922 COL1A2
PLAG1
collagen, type I, alpha 2
pleiomorphic adenoma gene 1
chr6_-_139654807 3.832 NM_153235
TXLNB
taxilin beta
chr3_-_39209075 3.797 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr1_-_199657468 3.721 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr11_-_85107569 3.707 NM_206929
SYTL2
synaptotagmin-like 2
chr22_+_24468168 3.701 MYO18B
myosin XVIIIB
chr2_-_162808123 3.693 NM_004460
FAP
fibroblast activation protein, alpha
chr2_-_105421661 3.588 NM_201557
FHL2
four and a half LIM domains 2
chr12_-_55931172 3.572 NM_145064
STAC3
SH3 and cysteine rich domain 3
chr22_+_24468110 3.393 NM_032608
MYO18B
myosin XVIIIB
chr1_-_199613406 3.293 TNNT2
troponin T type 2 (cardiac)
chr1_-_199613427 3.233 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chrX_-_77801480 3.163 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr10_-_69095362 3.015 NM_001127384
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr2_+_238712101 3.010 NM_198582
KLHL30
kelch-like 30 (Drosophila)
chr3_-_102194938 2.868 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr9_+_96806235 2.821 C9orf3
chromosome 9 open reading frame 3
chr10_+_111755715 2.796 NM_019903
ADD3
adducin 3 (gamma)
chr8_-_122722674 2.776 NM_005328
HAS2
hyaluronan synthase 2
chr3_-_115825742 2.755 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chrX_-_142549984 2.731 NM_001184750
SLITRK4
SLIT and NTRK-like family, member 4
chr4_+_120276386 2.678 NM_016599
MYOZ2
myozenin 2
chr20_+_19903778 2.660 RIN2
Ras and Rab interactor 2
chr3_+_8750485 2.648 NM_033337
NM_001234
CAV3

caveolin 3

chr2_-_179623030 2.606 NM_173648
CCDC141
coiled-coil domain containing 141
chr16_+_14187965 2.586 MKL2
MKL/myocardin-like 2
chr12_+_118100977 2.523 NM_014365
HSPB8
heat shock 22kDa protein 8
chr10_-_95231933 2.488 NM_013451
NM_133337
MYOF

myoferlin

chr7_+_18501876 2.482 NM_014707
NM_178423
HDAC9

histone deacetylase 9

chr3_-_11585264 2.348 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr8_-_72431274 2.340 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr2_-_189752575 2.306 NM_000393
COL5A2
collagen, type V, alpha 2
chr3_+_139550368 2.306 MRAS
muscle RAS oncogene homolog
chr5_-_83052606 2.227 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr17_-_10265991 2.190 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr10_+_80569464 2.189 ZMIZ1
zinc finger, MIZ-type containing 1
chr4_-_186934059 2.127 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr3_+_35696119 2.103 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr3_+_35658852 2.089 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr6_-_76259976 2.066 NM_015687
FILIP1
filamin A interacting protein 1
chrX_+_152699616 2.059 NM_001170760
NM_001170761
NM_014370
SRPK3


SRSF protein kinase 3


chr8_-_49996353 2.023 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr14_+_23670514 2.011 NM_203402
FITM1
fat storage-inducing transmembrane protein 1
chr14_+_99309688 2.003 EML1
echinoderm microtubule associated protein like 1
chr3_+_139550134 1.992 NM_001085049
MRAS
muscle RAS oncogene homolog
chr19_+_23091616 1.929 ZNF730
zinc finger protein 730
chr10_+_86174665 1.923 FAM190B
family with sequence similarity 190, member B
chr11_+_5667494 1.911 NM_006074
TRIM22
tripartite motif containing 22
chr1_-_229071957 1.871 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr4_-_177427252 1.821 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr4_+_169789327 1.813 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr1_-_116112684 1.742 CASQ2
calsequestrin 2 (cardiac muscle)
chr4_+_146820805 1.741 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr7_+_154943466 1.725 NM_001427
EN2
engrailed homeobox 2
chr7_+_18502342 1.662 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr6_-_130224108 1.642 NM_001010876
C6orf191
chromosome 6 open reading frame 191
chr1_-_31618405 1.632 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr1_-_85816520 1.626 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_+_144124547 1.624 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr1_-_16217025 1.619 HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr11_+_5667392 1.605 TRIM22
tripartite motif containing 22
chr21_-_35174742 1.603 RUNX1
runt-related transcription factor 1
chr5_-_142057692 1.595 NM_001144934
NM_001144935
FGF1

fibroblast growth factor 1 (acidic)

chr21_+_29439768 1.578 C21orf7
chromosome 21 open reading frame 7
chr1_-_116112853 1.570 CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_165768798 1.569 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr8_+_107807415 1.559 NM_001198534
NM_001198535
OXR1

oxidation resistance 1

chrX_-_142550535 1.553 NM_173078
SLITRK4
SLIT and NTRK-like family, member 4
chr15_+_76345577 1.550 NM_001130183
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr7_+_28415495 1.549 LOC401317
hypothetical LOC401317
chr3_+_190147633 1.546 TPRG1
tumor protein p63 regulated 1
chr6_+_136214495 1.541 NM_018945
PDE7B
phosphodiesterase 7B
chr11_+_35922106 1.537 NM_174902
LDLRAD3
low density lipoprotein receptor class A domain containing 3
chr20_+_60558104 1.524 NM_178463
C20orf166
chromosome 20 open reading frame 166
chr2_+_233099113 1.522 NM_000751
CHRND
cholinergic receptor, nicotinic, delta
chr3_-_113842652 1.514 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr10_+_70172257 1.506 CCAR1
cell division cycle and apoptosis regulator 1
chr10_-_62373828 1.505 NM_014836
RHOBTB1
Rho-related BTB domain containing 1
chr3_-_113842553 1.505 CCDC80
coiled-coil domain containing 80
chr17_+_39603599 1.483 NM_080863
ASB16
ankyrin repeat and SOCS box containing 16
chr11_-_19180092 1.482 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr2_-_210876560 1.473 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr18_+_12397894 1.460 NM_001142405
NM_006553
SLMO1

slowmo homolog 1 (Drosophila)

chr17_+_65677255 1.457 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr15_+_61676604 1.435 NM_203373
FBXL22
F-box and leucine-rich repeat protein 22
chr17_+_42641712 1.432 NM_002476
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr8_+_70541412 1.426 NM_001128204
NM_015170
SULF1

sulfatase 1

chr2_+_149603226 1.418 NM_177964
LYPD6B
LY6/PLAUR domain containing 6B
chr12_-_68379331 1.414 NM_032735
BEST3
bestrophin 3
chr3_+_50291521 1.401 NM_153215
C3orf45
chromosome 3 open reading frame 45
chr16_-_31347151 1.399 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr1_-_151784889 1.389 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr12_-_21985433 1.387 ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr2_+_201182187 1.376 AOX1
aldehyde oxidase 1
chr3_+_100840129 1.356 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr11_+_1897374 1.348 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr1_+_158352143 1.342 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr12_-_16650687 1.331 LMO3
LIM domain only 3 (rhombotin-like 2)
chr22_-_28972683 1.330 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr17_-_10362583 1.327 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr10_+_88418243 1.325 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr10_-_92671005 1.319 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_116112921 1.315 NM_001232
CASQ2
calsequestrin 2 (cardiac muscle)
chr19_+_43847049 1.297


chr6_+_42896771 1.296 NM_015349
KIAA0240
KIAA0240
chr1_+_201364050 1.291 ADORA1
adenosine A1 receptor
chr2_+_102744921 1.282 NM_144632
TMEM182
transmembrane protein 182
chr1_+_25629968 1.254 NM_018202
TMEM57
transmembrane protein 57
chr1_+_12325632 1.249 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_-_154727014 1.245 MEF2D
myocyte enhancer factor 2D
chr19_-_20540380 1.239 NM_001159293
ZNF737
zinc finger protein 737
chr10_+_91082218 1.219 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chrX_+_70438352 1.191 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr1_-_115039614 1.172 NM_000036
NM_001172626
AMPD1

adenosine monophosphate deaminase 1

chr12_-_16650697 1.172 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr13_-_59223074 1.150


chr17_-_24491521 1.149 MYO18A
myosin XVIIIA
chr1_+_242283129 1.148 NM_006352
ZNF238
zinc finger protein 238
chr2_+_220007943 1.144 NM_005876
SPEG
SPEG complex locus
chr3_+_185300660 1.142 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr10_-_69125932 1.130 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr10_-_121592020 1.124 MCMBP
minichromosome maintenance complex binding protein
chr4_-_23500706 1.121 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr3_-_139317140 1.115 NM_173543
DZIP1L
DAZ interacting protein 1-like
chr1_+_78243181 1.114 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr12_-_49689295 1.108 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr18_-_3209986 1.094 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr9_+_115367122 1.088 NM_134427
RGS3
regulator of G-protein signaling 3
chr14_-_88090641 1.087 NM_007039
PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr5_-_140875591 1.081 DIAPH1
diaphanous homolog 1 (Drosophila)
chr4_-_138673078 1.071 NM_019035
PCDH18
protocadherin 18
chr4_+_86918870 1.069 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr3_+_8518539 1.068 LMCD1
LIM and cysteine-rich domains 1
chr3_+_137224266 1.058 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr4_+_129950222 1.054 NM_024900
NM_199320
PHF17

PHD finger protein 17

chr1_+_144236346 1.047 NM_003637
ITGA10
integrin, alpha 10
chr2_-_151052391 1.045 NM_005168
RND3
Rho family GTPase 3
chr1_+_26220852 1.045 NM_004455
EXTL1
exostoses (multiple)-like 1
chr5_+_121493113 1.044 NM_207317
ZNF474
zinc finger protein 474
chr1_+_144236398 1.041 ITGA10
integrin, alpha 10
chr13_-_97916768 1.040 STK24
serine/threonine kinase 24
chr3_-_147361465 1.027 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr17_+_42641426 1.026 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr9_+_115396020 1.025 NM_144489
RGS3
regulator of G-protein signaling 3
chr11_+_64838882 1.023 NM_006779
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr4_-_143987053 1.022 NM_001101669
NM_003866
INPP4B

inositol polyphosphate-4-phosphatase, type II, 105kDa

chr14_+_95792299 1.014 NM_000710
BDKRB1
bradykinin receptor B1
chr5_+_92944680 1.012 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr6_+_131613196 1.008 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr6_-_131333173 1.001 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr12_-_49689255 0.999 SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr1_+_26220895 0.998 EXTL1
exostoses (multiple)-like 1
chr1_-_202595666 0.994 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr10_+_88418147 0.984 NM_001171610
LDB3
LIM domain binding 3
chr10_+_5478521 0.972 NM_005863
NET1
neuroepithelial cell transforming 1
chr20_+_11846536 0.944 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr19_+_4983899 0.942


chr4_+_114190233 0.918 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr11_-_62213577 0.908 LRRN4CL
LRRN4 C-terminal like
chr11_+_1816808 0.895 NM_003282
TNNI2
troponin I type 2 (skeletal, fast)
chr4_+_86918882 0.891 ARHGAP24
Rho GTPase activating protein 24
chr12_+_15590811 0.888 PTPRO
protein tyrosine phosphatase, receptor type, O
chr11_-_62213946 0.885 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr2_+_5750229 0.882 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chrX_-_11194015 0.880 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr5_+_140730014 0.879 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr3_-_55489973 0.870 WNT5A
wingless-type MMTV integration site family, member 5A
chr11_+_65023218 0.870


chr17_-_26672757 0.865 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr12_+_119224506 0.862 NM_012240
SIRT4
sirtuin 4
chr11_+_65023038 0.861 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr7_+_30917939 0.859 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr8_+_70541631 0.857 SULF1
sulfatase 1
chr3_+_8518508 0.852 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr8_-_62764839 0.848 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr9_-_14769530 0.845 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr8_+_17866373 0.845 PCM1
pericentriolar material 1
chr4_-_5881271 0.834 CRMP1
collapsin response mediator protein 1
chr12_-_242255 0.831 NM_001190997
NM_016615
SLC6A13

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

chr9_+_70161634 0.828 NM_021965
PGM5
phosphoglucomutase 5
chr4_+_41057322 0.827 LIMCH1
LIM and calponin homology domains 1
chr10_+_91142301 0.826 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr6_-_50039776 0.825 NM_001037499
DEFB114
defensin, beta 114

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.70 2.40e-06 GO:0061061 muscle structure development
3.07 9.24e-06 GO:0003012 muscle system process
2.95 1.57e-05 GO:0007517 muscle organ development
2.75 2.27e-03 GO:0006936 muscle contraction
4.61 3.32e-02 GO:0006941 striated muscle contraction
4.61 3.32e-02 GO:0030049 muscle filament sliding
4.61 3.32e-02 GO:0033275 actin-myosin filament sliding
2.71 4.12e-02 GO:0042692 muscle cell differentiation
4.49 4.40e-02 GO:0070252 actin-mediated cell contraction

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.95 3.59e-14 GO:0030016 myofibril
4.80 4.61e-14 GO:0043292 contractile fiber
4.95 9.76e-14 GO:0044449 contractile fiber part
5.07 2.01e-12 GO:0030017 sarcomere
5.50 1.16e-06 GO:0031674 I band
5.72 1.59e-05 GO:0030018 Z disc
6.04 2.74e-02 GO:0032982 myosin filament
7.16 2.92e-02 GO:0031672 A band

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.97 3.49e-02 GO:0008307 structural constituent of muscle